Music: Timothy Blais
Huxley
B•Mac oh
Carrol Carrol
Could Stephen Jay yeah
Davidson (and) Peter Go!
See One cell divide and decide on a thousand fates
Did you ever figure how they know？（B.Mac）
We are built of modules combine in a planned out way
Each new piece must be told where to go Oh
Now there's a science helping us to understand
How our cells encode this architectural plan
Signalling each other with genetic tools Oh oh yeah
Wow Phenotype the interface for mouse and man
Genotype the files and the subprograms
What then are the switch, circuit boards and boot code
Evo-devo Looking at the logic in the ways that we grow
Every gene directed by a signal key code
Proteins that can activate, enhance or veto
Evo-devo Signals are controlled by other genes that signal
Calculating in a network Labyrinthal
Where the heart and liver and the hands and feet go (Signal*5)
Signal mapping tells each other what it ought to be yo
With circuits so deeply built upon They're older than the paleo
The Paleozoic era baby
In a crucial pathway changes tend to get torpedoed
Where they go calamity goes As this cyclopic sheep knows
See down they cascade like a domino
Like you and I drosophila
The path that makes us optical
Was laid a long long time ago
Back before we blew up the Cambrian like a bomb bomb
Now my eye protein can make you see out of your bom bom
And hedgehog and its relatives like Indian and Sonic
Set up set up in a gradient on segments embryonic
Spilt fore brains and asymmetric parts depend upon it
Flipping on genetic switches and logic
From devo to evo adult and embryo
Mostly don't evolve in the genes of the genome
Safer the mutation aimed at regulation
Keep the building blocks and swap their activation
From devo to evo parts have alter egos
Homologs evolved from repeats in the schema
Switch a couple bases in the proper places
You'll be watching flies grow legs out of their faces Oh yeah
Evo-devo stick around for Modern Synthesis the sequel
Only by combining can a new theory grow
Evolution and development amigos
Evo-devo signals trigger patterns of complexity so
Switching up the switch of a signalling node
Gives a modular and simple way to evolve (switch*5)
Look at how our spinal segments generate a neat row
Built on molecular clock one cycle one vertebra
One vertebra one vertebra baby
Speeding up its rate is snake's developmental cheat code
That and where a lizard's feet grow
They turn off distal aminos
Evo-devo this is how we go from single cells to people
Every generation and in life primeval
Life in variations endless and beautiful Bababoom
From devo to evo larva to mosquito
Patterns are resolved as the signals proceed yo
Map out a gene with a glow tag
Kill it with a morpholino
Short oligo morpholino baby
From devo to evo voyage of the Beagle
Body plans evolve when protein steer the genome
In this manner life's beauty grows aesthetica in vivo
Evo-devo